As a result, we found for the first time that the miR-17-92 cluster, which comprises seven miRNAs and resides in intron 3 of the C13orf25 gene at 13q31.3, is markedly overexpressed in lung cancers, especially with small-cell lung cancer histology.

Deletions in the MIR17HG cluster (miR-17~92 in mice), detected in a subset of patients with Feingold syndrome, represent the first miRNA mutations to be

High expression of. MYB in blast cells from 2 Ph+ leukemia patients correlated positively. 28 May 2014 The polycistronic miR-17-92 cluster is the first microRNA cluster shown to play a role in tumorigenesis. It has two other paralogs in the human 14 Jun 2017 DELETION OF CARDIAC miR-17-92 CLUSTER INCREASES ISCHEMIC/ REPERFUSION. INJURY VIA PTEN UPREGULATION. By: Meeta 15 Aug 2013 Two paralog miRNA clusters (miR-106a–363 and miR-106b–25) differ from the miR-17–92 cluster in their number of miRNAs. Oncogenic Mir-92 has been mapped to the human genome as part of a larger cluster at This long precursor sequence is a component of the mir-17-92 cluster which including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC. Differential miRNA rather than Nyliga expressionsprofileringsstudier rapporterade mikroRNA (miRNAs) (och i synnerhet miR-17-92-kluster) som användbara verktyg för differentiering av The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma.

Mirna 17-92 cluster

Expression and regulation of the miRNA-17-92 cluster in tumor cells Expression and functions of miR-17/20a. The miRNA-17-92 cluster may be highly expressed in a wide range of tumor cells and types of cancer, such as lung, breast, pancreatic, prostate and thyroid cancer, as well as lymphomas (7,14). Therefore, it is also referred to as MiR-17-92 cluster is an oncogenic miRNA cluster that is implicated in several cancers, although its role in hepatocarcinogenesis has not been clearly defined. In this study, we show that the miR-17-92 cluster is highly expressed in human hepatocellular carcinoma (HCC) tissues compared to the non-tumorous liver tissues by RT-PCR and in situ hybridization analyses.

1 Background. Psoriasis is an immune‐mediated inflammatory skin disease, characterized by keratinocyte hyperproliferation and altered differentiation, The miR-17~92 cluster in cancer pathogenesis. First evidence that the miR-17~92 cluster may be involved in tumori-genesis was provided by studies showing that the C13orf25 locus, which encodes the primary transcript of the miR-17~92 cluster, is frequently … Increasing evidence indicates that microRNAs (miRNAs) may be critical players in spermatogenesis.

Results. Identification of miR-17-92 cluster overexpression preferentially in small-cell lung cancer. We first selected 21 miRNA genes as of possible interest based on target prediction by TargetScan ( 9) and searched for alterations by Northern blot analysis, resulting in the identification of marked overexpression of miR-19a, miR-20, miR-106a, and miR-106b ( Fig. 1A).

& et al. (2015). MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer.

The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play an important role in this process by regulating crucial developmental genes. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in

In an elegant study, Ventura et al. studied the function of the miR-17~92 cluster and its paralogs miR-106a~363 and miR-106b~25 by generating mice deficient for each of these miRNA clusters.14 While The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia.

We have found that it is also frequently amplified and the miRNAs are aberrantly overexpressed in mixed lineage leukemia (MLL)-rearranged acute leukemias. The AUC for combined detection by using the 6 miRNAs of miR-17–92 cluster was higher than that for each miRNA alone (Fig. 4A). Overall, the sensitivity and specificity of the combined detection for predicting disease progression in patients with GC were superior to those with each miRNA alone. A polycistronic miRNA cluster miR-17-92 plays a role in the control of cell proliferation and angiogenesis. This cluster consists of seven miRNAs: miR-17-5p, miR-17-3p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92. Like E2F1 gene, the cluster is transcriptionally activated by the proto-oncogene c-Myc.
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Although miR-17-92 cluster are located at 13q31.3, the expression of miR-18, miR-19 and miR-20 (especially miR-19) in patients with del (13q14) was higher than those without del (13q14). Patients with miR-17, miR-20 and miR-92 high-expression had shorter PFS compared to those with miR-17, miR-20 and miR-92 low-expression. MicroRNA-17-92 (miRNA-17-92 or miR-17-92) is a miRNA cluster that regulates cell growth and immunity, but the role of miR-17-92 cluster in keratinocytes and its relation to skin diseases have not been well investigated.

An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster expression.
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2020-06-17

https: The miR17-92 cluster comprises a cluster of six miRNAs on chromosome 13 that is transcribed as a single polycistronic unit (14). Despite the wealth of information about the biological effects of the miR17-92 cluster in cancer cells (15), the effect of this cluster on regulation of neural progenitor cells after stroke is unknown. MiR-17-92 cluster is a direct Nanog target in NSCWe first validated profiling data by single assay QPCR (Figure 2A).

The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. This page in English. Författare

The miRNA-17 ∼ 92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. Leukemia 26, 1064–1072 (2012). https: MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J Biol Chem.

A common secondary genomic alteration detected in MCL is chromosome 13q31-q32 gain/amplification, which targets a microRNA (miRNA) cluster, miR-17∼92… MiR-17-92 cluster is an oncogenic miRNA cluster that is implicated in several cancers, although its role in hepatocarcinogenesis has not been clearly defined. In this study, we show that the miR-17-92 cluster is highly expressed in human hepatocellular carcinoma (HCC) tissues compared to the non-tumorous liver tissues by RT-PCR and in situ hybridization analyses. The mircoRNA-17-92 cluster encoded by the miR-17-92 host gene is first found in malignant B-cell lymphoma. Recent research identifies the miR-17-92 cluster as a crucial player in the development of the immune system, the heart, the lung, and oncogenic events.